The Los Angeles Rams (2-1) will hit the road to play in another massive NFC West showdown. The Rams coming off a big divisional win against the Arizona Cardinals, will face the San Francisco 49ers (1-2) on Monday Night Football this week.
The Rams will be looking to extend their current winning streak to three games, while the 49ers will be trying to right the ship after already suffering two frustrating losses in the first three weeks of the season.
The 49ers are the favorite to win at most online gambling sites in the US, with FanDuel Sportsbook giving the Rams +2.5 points on the road.
Rams vs. 49ers Betting Preview
| Spread | Moneyline | Total | |
| Rams | +2.5 (-114) | +110 | O 42.5 (-108) |
| 49ers | -2.5 (-106) | -130 | U 42.5 (-112) |
Rams Look to Reverse Luck
Over the previous several seasons, the matchup against Kyle Shannahan and the 49ers has historically proven to be Sean McVay and Co’s kryptonite, with the Rams winning only once in the last seven meetings. However, it’s worth noting that the one game in which the Rams did manage to win over the 49ers was last year’s NFC Championship game, arguably getting the better end of the deal when all’s said and done.
After an opening day loss at home to the Buffalo Bills, the Rams bounced back to their winning ways in Week 2 against the Falcons and Week 3 against the Cardinals.
So far this season, neither side has been playing at the level expected before the season began, so it will be intriguing to see who comes out on top on Monday Night. The winner of this early season matchup will have a considerable advantage in claiming the NFC West title at the end of the regular season.
The 49ers are now without their quarterback and star-in-the-making Trey Lance, who suffered a horrific season-ending injury in Week 2. In his place, the 49ers will have Jimmy Garappolo back under center for the rest of the season. While it may lower the potential offensive ceiling for the 49ers, having Garappolo leading the offense does provide a sense of predictability and assuredness.
Garappolo and the offense struggled against the Denver Broncos on Sunday night, only managing to put up 10 points after guiding the 49ers to a comfortable win over the Cardinals in Week 2. Without the preseason that a starting quarterback is used to, it’s clear he needs to iron out some kinks in his game if the 49ers are to make the playoffs this season.
On the other side of the ball, the 49ers have a championship-caliber defense this year, which should receive its first stress test on Monday night against Matthew Stafford and his arsenal of star receivers. Going up against the 49ers, you have the reigning Super Bowl Champions who look like they just may be starting to shake off their Super Bowl hangover.
Rams vs. 49ers Betting Trends
- Los Angeles is 4-0 on the moneyline in their last four away games.
- Los Angeles is 2-1 ATS in 2022.
- San Francisco is 5-0 ATS in its last five home games.
